Neocate^® Syneo^® Junior – FAQs – HCPs

What is Neocate^® Syneo^® Junior?

Neocate Syneo Junior is an unflavored, nutritionally complete, hypoallergenic amino acid-based formula with Syneo, a blend of pre- and probiotics, specifically designed for children 1-10 years of age with food allergies and related gastrointestinal (GI) and allergic conditions.

Neocate Syneo Junior is our newest addition to the Neocate Junior line as an upgrade and replacement of Neocate Junior with Prebiotics, unflavored. Neocate Syneo Junior provides trusted food allergy symptom relief and tailored nutrition like the rest of our Neocate Junior line.

What are the medical indications for Neocate Syneo Junior?

Neocate Syneo Junior is indicated for children 1-10 years of age for the dietary management of cow milk allergy, multiple food allergies, and related gastrointestinal (GI) and allergic conditions, including eosinophilic GI disorders (EGIDs), food protein-induced enterocolitis syndrome (FPIES), and gastroesophageal reflux related to food allergies.

Neocate Syneo Junior is not indicated for the management of malabsorption and is not recommended for use in children with short bowel syndrome (SBS) unless a risk and benefit analysis is completed by a healthcare professional, and the patient is monitored.

My patient is on Neocate Junior with Prebiotics, unflavored and is over the age of 10, what alternative products are available?

We have several options for those who require an amino acid-based formula and are over the age of 10.

• Neocate Junior unflavored without prebiotics (powder)
• Neocate Junior with prebiotics (powder)
   o Vanilla
   o Strawberry
   o Chocolate
• Neocate Splash (ready to feed)
   o Vanilla
   o Orange-Pineapple
   o Grape
   o Tropical Fruit
   o Unflavored

The above options continue to be available and are all indicated for individuals one year of age and older with any of the labeled medical indications.

When should Neocate Syneo Junior not be used?

Like other probiotic-containing products, we do not recommend the use of Neocate Syneo Junior in those who are immunocompromised. Neocate Syneo Junior is not recommended for use in those with a central venous catheter or post-pyloric feeding tube, unless directed or supervised by a healthcare professional. Neocate Syneo Junior is for oral or tube feeding only and not for parenteral use. Lastly, Neocate Syneo Junior is not indicated in those with malabsorption and is not recommended for use in those with short bowel syndrome (SBS) unless a risk and benefit analysis is completed by a healthcare professional, and the patient is monitored.

My patient is on Neocate Junior with Prebiotics, unflavored and has short bowel syndrome (SBS) and/or malabsorption, what alternative products are available?

For those who are unable to receive Neocate Syneo Junior, we have a number of alternatives. Neocate Junior unflavored without prebiotics, a variety of Neocate Junior with prebiotics flavor options, and five flavors of our ready-to-feed Neocate Splash are all available indicated for SBS and malabsorption.

Neocate Syneo Junior is not indicated for the management of malabsorption and is not recommended for use in children with SBS unless a risk and benefit analysis is completed by a healthcare professional, and the patient is monitored.

Once you and your patient and/or patient’s caregiver have decided on an alternative product, our Nutricia Navigator team can assist your patient and/or patient’s caregiver with obtaining the product. Our Nutricia Navigator team can be reached at 1-800-365-7354 (9 am – 6 pm ET) or via email at nutricianavigator@nutricia.com.

Can my patient transition from Neocate Junior with Prebiotics, unflavored to Neocate Syneo Junior without a transition period?

Neocate Syneo Junior is an unflavored, powdered, nutritionally complete hypoallergenic formula. Most children will be able to transition from Neocate Junior with Prebiotics, unflavored to Neocate Syneo Junior without a transition period and without any issues. If your patient requires a slower transition, we recommend the fading approach. Fading is a strategy where a small amount of a new formula is mixed with something the child is used to (such as expressed human milk, another formula, or another beverage), gradually increasing the ratio of new to old over time. We provide more information regarding formula transition in our transition guide—“A Guide to Transitioning.”

Please note that unlike Neocate Junior with Prebiotics, unflavored, Neocate Syneo Junior is not indicated for the management of malabsorption and is not recommended for use in children with short bowel syndrome (SBS) unless a risk and benefit analysis is completed by a healthcare professional, and the patient is monitored.

What are the differences between Neocate Syneo Junior and Neocate Junior with Prebiotics, unflavored?

Neocate Syneo Junior is a safe, hypoallergenic, unflavored, nutritionally complete amino acid-based formula like Neocate Junior with Prebiotics, unflavored. The key differences include:

• Neocate Syneo Junior has the added benefit of the probiotic, Bifidobacterium breve M-16V.
• Neocate Syneo Junior is indicated in children one – 10 years of age whereas Neocate Junior with Prebiotics, unflavored is indicated in those one year of age and older.
• Slight differences in nutrient levels.
• Neocate Syneo Junior has different a storage recommendation and a different water temperature recommendation due to the added probiotic.
   o Once the Neocate Syneo Junior can is opened, replace can lid and use within 2 weeks.
   o Mixing Neocate Syneo Junior with water warmer than 104°F (40°C) or warming formula above 104°F (40°C) may lessen the benefits of the probiotic cultures.

Will the Neocate Syneo Junior mixing instructions differ from Neocate Junior with Prebiotics, unflavored?

When preparing the formula at the standard dilution of 30 kcal/fl oz (1 kcal/mL), the general guidance of mixing one unpacked, level scoop of powder to each one fluid ounce of water remains the same.

Due to the presence of probiotics in Neocate Syneo Junior, there is a difference in regard to the temperature of water that the formula should be mixed with. Mixing Neocate Syneo Junior with water warmer than 104°F (40°C) or warming the formula above 104°F (40°C) may lessen the benefits of the probiotic cultures.

Directions for preparation of Neocate Syneo Junior:

1. Wash hands thoroughly and clean the preparation area.
2. To make the standard dilution (30 kcal/fl oz), add 1 unpacked, level scoop (7.6 g) of powder to each 1 fl oz of water.
3. Stir, or cover and shake, until the powder has dissolved.

How should I store Neocate Syneo Junior?

Store unopened or opened cans in a cool, dry place. Once opened, replace can lid and use within two weeks. Do not store at extreme temperatures.

Once prepared, Neocate Syneo Junior should be fed immediately OR refrigerated immediately and used within 24 hours. Once feeding begins, use within one hour or discard.

Do the storage instructions for Neocate Syneo Junior differ compared to Neocate Junior with Prebiotics, Unflavored?

Yes, once opened, Neocate Syneo Junior should be used within two weeks which differs from the recommendation of using an opened can of Neocate Junior with Prebiotics, unflavored within one month.

Both products should be stored in a cool, dry place (unopened and opened cans), and should not be stored at extreme temperatures.

What are the codes for Neocate Syneo Junior?

How can I request a sample of Neocate Syneo Junior for my patient to try?

Samples of Neocate Syneo Junior will be available mid-June. You can request sample packs of other Neocate Junior options and Neocate Splash here.